李思怡

个人简介

姓名：李思怡科研团队：粮油科学与技术团队

邮箱：lisiyi0809@126.com       政治面貌：群众

职称：讲师                     入职时间：2025.07

李思怡，博士，渤海大学讲师。主要从事益生菌活性物质的性质与功能分析、特色发酵食品及农产品的资源利用等方面的研究，近5年来发表SCI论文7篇，发表EI论文1篇，申请国家发明专利1件

教育背景

1.2021.09-2025.06：大连工业大学，食品科学与工程，工学博士

2.2018.09-2021.06：大连工业大学，食品科学与工程，工学硕士

3.2014.09-2018.06：山西中医药大学，食品科学与工程，工学学士

工作经历

  2025.07－至今，渤海大学食品学院，讲师

学术论文

1. Siyi Li, Zichen Li, Yanfeng Tuo, Guangqing Mu, Shujuan Jiang*. Mechanisms of casein-derived immunomodulatory peptides maintaining immune homeostasis via regulating gut microbiota in a cyclophosphamide-induced mouse model[J]. Journal of Agricultural and Food Chemistry. 2025, 73(40): 25394-25412.

2. Siyi Li, Zichen Li, Yanfeng Tuo, Guangqing Mu, Shujuan Jiang*. Immunomodulatory effect, digestive stability, and action mechanism of casein peptide SPAQILQW activating macrophages via N-terminal serine[J]. Journal of Dairy Science. 2025, 108(7): 6617-6633.

3. Siyi Li, Yutong Jiang, Lai Jiang, Yanfeng Tuo, Guangqing Mu, Shujuan Jiang*. New insights into the structure-activity relationship of a novel immunomodulatory peptide (HPHPHLSF) from casein hydrolyzed by Kluyveromyces marxianus JY-1: molecular docking, interaction evaluation, and HOMO analysis[J]. Journal of Agricultural and Food Chemistry. 2024, 72(40): 22158-22172.

4. Siyi Li, Yutong Jiang, Zhiqi Cao, Yanfeng Tuo, Guangqing Mu, Shujuan Jiang*. Novel casein-derived immunomodulatory peptide PFPEVFG: Activity assessment, molecular docking, activity site and mechanism of action[J]. Journal of Dairy Science. 2024，107(11): 8852-8864.

5. Siyi Li, Yutong Jiang, Lai Jiang, Yanfeng Tuo, Guangqing Mu*, Shujuan Jiang*. Safety evaluation, hydrolysis activity of Kluyveromyces marxianus JY-1 and its application to obtain immunomodulatory peptide from bovine casein[J]. Food Bioscience. 2023, 56: 103409.

6. Siyi Li, Linjie Guo, Jinhong Gu, Guangqing Mu, Yanfeng Tuo*. Screening lactic acid bacteria and yeast strains for soybean paste fermentation in northeast of China. Food Science & Nutrition, 2023, 11(8), 4502-4515.

7. Siyi Li, Xue Du, Lu Feng, Guangqing Mu, Yanfeng Tuo*, et al. The microbial community, biogenic amines content of soybean paste, and the degradation of biogenic amines by Lactobacillus plantarum HM24[J]. Food science & nutrition, 2021, 9(12), 6458-6470.

8. 李思怡,姜雨彤,妥彦峰,吴晓萌，牟光庆，姜淑娟*.微生物发酵法制备乳源生物活性肽研究进展[J].食品科学,2023,44(21):312-321.

代表性专利

1. 姜淑娟, 李思怡, 妥彦峰, 牟光庆.一种马克思克鲁维酵母及其在制备具有免疫调节作用酪蛋白水解物中的应用[P].辽宁省:CN202310735018.5.

承担教学

研究生《未来食品与工程前沿进展》