闫孟红

个人简介

姓名：闫孟红     科研团队：食品营养与安全

邮箱：yanmenghong1@bhu.edu.cn      政治面貌：中共党员

职称：副高级                       入职时间：2025.07

闫孟红，博士，渤海大学副教授，硕士生导师。近年来研究主要围绕RNA结构、修饰及功能展开，已建立起LC-MS/MS高通量检测RNA修饰的方法平台，利用该方法发现精子tsRNAs上存在多种修饰，并发现肥胖小鼠精子RNA中携带有传递父代获得性性状的表观遗传信息并进一步发现精子tsRNAs及其修饰在精子跨代遗传信息传递中起着重要的调控作用；后续研究发现tsRNAs分子末端存在磷酸和环磷酸修饰并建立起PANDORA-seq测序平台。到目前为止共发表文章17篇，研究成果发表在Science, Nature Cell Biology，Analytical Chemistry等专业期刊上，其中发表在Science上的文章被WEB OF SCIENCE™列为“高被引论文”。该研究入选科技部评选的“2016 年度中国科学十大进展”和中国科协评选的“2016 年中国生命科学领域十大进展”。目前研究方向：1) RNA等生物活性大成分的递送及功能机制，2) 食源性活性成分在慢性代谢性疾病中的作用及机制。

主持并参与了多个国家基金委的相关研究课题。作为业务骨干参与重点研发计划（2018YFC1004502）项目，曾主持国家自然科学基金面上项目2项（编号31670830和81472181），国家自然科学基金青年基金（编号30900250）1项，作为子课题负责人参与中国科学院战略性先导科技专项（A类）子课题；中国博士后科学基金资助1项；曾参与国家自然科学基金委、国家科技重大专项、上海市科委等课题。

教育背景

工作经历

学术论文

作为第一作者/共同一作发表的论文：

1. Junchao Shi*, Yunfang Zhang*, Dongmei Tan*, Xudong Zhang*, Menghong Yan*(共同一作), Ying Zhang*, Reuben Franklin *, Marta Shahbazi, Kirsty Mackinlay, Shichao Liu, Bernhard Kuhle, Emma R. James, Liwen Zhang, Yongchun Qu, Qiwei Zhai, Wenxin Zhao, Linlin Zhao, Changcheng Zhou, Weifeng Gu, Jernej Murn, Jingtao Guo, Douglas T. Carrell, Yinsheng Wang, XuemeiChen, Bradley R. Cairns, Xiang-lei Yang, Paul Schimmel, Magdalena Zernicka-Goetz, Sihem Cheloufi^#, Ying Zhang^#, Tong Zhou^#, Qi Chen^#. PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications. Nature Cell Biology. 2021,23(4):424-436. *Co-first authors; #Corresponding authors. (IF: 17.3) 

2. Menghong Yan. Chapter 12 - The paternal diet regulates the offspring epigenome and health, Editor(s): Bradley S. Ferguson, Nutritional Epigenomics. Academic Press, 2019, V14, 191-200, ISSN 25425358, ISBN 9780128168431, https://doi.org/10.1016/B978-0-12-816843-1.00012-6. (Invited review)

3. Qi Chen*^,# , Menghong Yan*(共同一作), Zhonghong Cao*, Xin Li*, Yunfang Zhang*, Junchao Shi*, Gui-Hai Feng, Hongying Peng, Xudong Zhang, Ying Zhang, Jingjing Qian, Enkui Duan^#, Qiwei Zhai^#, Qi Zhou^#. Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science. 2016, 351(6271): 397-400. *Co-first authors; #Corresponding authors. (IF: 44.7)

Highligted by
Leslie M. Sperm RNA fragments modify offspring metabolism. Science 2016;351(6268):13.
Waldron D. Non-coding RNA: Inheritance of diet-induced metabolic changes via tsRNAs. Nat Rev Genet 2016;17(3):128.
Watson ED. Transferring Fragments of Paternal Metabolism to the Offspring. Cell Metab 2016;23(3):401-402.
Gapp K, Miska EA. tRNA fragments: novel players in intergenerational inheritance. Cell Res 2016;26(4):395-396.

4. Menghong Yan and Qiwei Zhai. Sperm tsRNAs and acquired metabolic disorders. Journal of Endocrinology. 2016, 230(3):F13-8 (Invited review IF: 3.4)

5. Menghong Yan, Yuangao Wang, Ya-nan Hu, Yan Feng, Changgui Dai, Jingxia Wu, Dongmei Wu, Fang Zhang, Qiwei Zhai. A high-throughput quantitative approach reveals more small RNA modifications in mouse liver and their correlation with diabetes. Analytical chemistry. 2013, 85(24): 12173–12181. (IF: 6.7)

6. Menghong Yan, Pi Cheng, Zhiyong Jiang, Yunbao Ma, Xuemei Zhang, Fengxue Zhang, Liumeng Yang, Yongtang Zheng, Jijun Chen. Periglaucines A–D, and anti-HBV and HIV-1 constituents from Pericampylus glaucus. Journal of natural products. 2008, 71(5):760–763. (IF: 3.3)

作为参与作者发表的论文：

1. Junchao Shi, Yunfang Zhang, Yun Li , Liwen Zhang, Xudong Zhang, Menghong Yan, Qi Chen, Ying Zhang. Optimized identification and characterization of small RNAs with PANDORA-seq. Nature Protocols. 2025,20: 3314–3338. ( IF: 16.0 )

2. Nanxi Geng, Ziqin Yu, Xingchao Zeng, Yuxuan Chen, Mengyao Sheng, Danhua Xu, Menghong Yan, Min Yang, Xinxin Huang. Pulse activation of retinoic acid receptor enhances hematopoietic stem cell homing by controlling CXCR4 membrane presentation. Stem cell reviews reports. 2025,21(1):68-79. ( IF: 4.5 )

3. Qi Chen^#, Xudong Zhang, Junchao Shi, Menghong Yan, Tong Zhou^#. Origins and evolving functionalities of tRNA-derived small RNAs. Trends in Biochemical Sciences. 2021,46(10):790-804. ^#Corresponding authors (IF: 11.6)  

4. Yalan Cheng, Jun Liu, Yi Luan, Zhiyuan Liu, Hejin Lai, Wuling Zhong, Yale Yang, Huimin Yu, Ning Feng, Hui Wang, Rui Huang, Zhishui He, Menghong Yan, Fang Zhang, Yan-Gang Sun, Hao Ying, Feifan Guo and Qiwei Zhai. Sarm1 Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice. Diabetes. 2019,68(11):2120-2130. (IF: 6.2)

5. Zhiyuan Liu, Yalan Cheng, Yi Luan, Wuling Zhong, Hejin Lai, Hui Wang, Huimin Yu, Yale Yang, Ning Feng, Feixiang Yuan, Rui Huang, Zhishui He, Fang Zhang, Menghong Yan, Hao Yin, Feifan Guo, Qiwei Zhai. Short-termtamoxifen treatment has long-term effects on metabolism in high-fat diet-fed mice with involvement of Nmnat2 inPOMC neurons, FEBS Letters. 2018, 592(19): 3305-3316. (IF: 3.0)

6. Yunfang Zhang, Xudong Zhang, Junchao Shi, Francesca Tuorto, Xin Li, Yusheng Liu, Reinhard Liebers, Liwen Zhang, Yongcun Qu, Jingjing Qian, Maya Pahima, Ying Liu, Menghong Yan, Zhonghong Cao, Xiaohua Lei, Yujing Cao, Hongying Peng, Shichao Liu, Yue Wang, Huili Zheng, Rebekah Woolsey, David Quilici, Qiwei Zhai, Lei Li, Tong Zhou, Wei Yan, Frank Lyko, Ying Zhang, Qi Zhou, Enkui Duan, and Qi Chen. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. Nature Cell Biology. 2018,20(5): 535-540 (IF: 17.3)

7. Yi Luan, Fang Zhang, Yalan Cheng, Jun Liu, Rui Huang, Menghong Yan, Yuangao Wang, Zhishui He, Hejin Lai, Hui Wang, Hao Ying, Feifan Guo, and Qiwei Zhai. Hemin Improves Insulin Sensitivity and Lipid Metabolism in Cultured Hepatocytes and Mice Fed a High-Fat Diet. Nutrients. 2017, 9(8): 805. (IF:4.8 )

8. Jun Liu, Ben Zhou, Menghong Yan, Rui Huang, Yuangao Wang, Zhishui He, Yonggang Yang, Changgui Dai, Yiqian Wang, Fang Zhang, Qiwei Zhai. CLOCK and BMAL1 regulate muscle insulin sensitivity via SIRT1 in male mice. Endocrinology. 2016, 157(6):2259-2269. (IF:3.8 )

9. Yuangao Wang, Yanan Hu, Chenxia Sun, Shu Zhuo, Zhishui He, Hui Wang, Menghong Yan, Jun Liu, Yi Luan, Changgui Dai, Yonggang Yang, Rui Huang, Ben Zhou, Fang Zhang, Qiwei Zhai. Down-regulation of Risa improves insulin sensitivity by enhancing autophagy. The FASEB Journal. 2016, 30(9): 3133-3145. (IF:4.4 )

10. Jingxia Wu, Fang Zhang, Menghong Yan, Dongmei Wu, Qiujing Yu, Yi Zhang, Ben Zhou, Michael W. McBurney and Qiwei Zhai. Wld^S Enhances Insulin Transcription and Secretion via a SIRT1-dependent Pathway and Improves Glucose Homeostasis. Diabe, tes. 2011, 60(12):3197–3207. (IF: 6.2)

11. Pi Cheng, Yunbao Ma, Shuying Yao, Quan Zhang, Enjun Wang, Menghong Yan, Xuemei Zhang, Fengxue Zhang, Jijun Chen. Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida. Bioorganic & Medicinal Chemistry Letters. 2007, 17(19): 5316–5320. (IF:2.9 )

代表性专利

无

承担教学

本科生《食品工程原理课程设计》等